Phase II study of helical tomotherapy for oligometastatic colorectal cancer

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Phase II study of helical tomotherapy for oligometastatic colorectal cancer.

BACKGROUND To evaluate the efficacy and toxicity of helical tomotherapy in the treatment of oligometastatic colorectal cancer (CRC) patients who were not amenable for metastasectomy and/or (further) systemic treatment. PATIENTS AND METHODS CRC patients with five or less metastases were enrolled. No limitations concerning dimension or localization of the metastases were imposed. Patients were ...

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Phase II study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer

BACKGROUND Complete metastasectomy provides a real chance for long-term survival in patients with oligometastatic colorectal cancer (CRC). For inoperable patients, we evaluated in this study intensity-modulated and image-guided radiotherapy (IMRT-IGRT) by helical tomotherapy. METHODS Twenty-four CRC patients with ≤ 5 metastases were enrolled, receiving a dose of 50 Gy in fractions of 5 Gy. No...

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A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastases

BACKGROUND Our research group has previously published a dosimetric planning study that demonstrated that a 60 Gy/10 fractions intralesional boost with whole-brain radiotherapy (WBRT) to 30 Gy/10 fractions was biologically equivalent with a stereotactic radiosurgery (SRS) boost of 18 Gy/1 fraction with 30 Gy/10 fractions WBRT. Helical tomotherapy (HT) was found to be dosimetrically equivalent t...

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Feasibility and response of helical tomotherapy in patients with metastatic colorectal cancer

PURPOSE To investigate the treatment outcome and the toxicity of helical tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC). MATERIALS AND METHODS We retrospectively reviewed 18 patients with 31 lesions from mCRC treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 lesions) were the most frequent sites. The planning target volume (PTV) ranged from...

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Helical tomotherapy for cancer treatment: a rapid health technology assessment.

OBJECTIVES Helical tomotherapy (HT) can be applied to treat complex malignant cancer with high-precise radiotherapy, and it can reduce the damage to normal tissues and improve treatment effects. But the procurement of HT must be approved by relevant departments of administration affairs. This study, appointed by the National Health and Family Planning Commission of China and undertook by the Na...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2011

ISSN: 0923-7534

DOI: 10.1093/annonc/mdq385